It's very Jewish, and though there are some Israeli characters it's mainly a paean to New York diaspora Jewish culture, though I don't think Pynchon is Jewish. He's got it down really well, though, the language, the preoccupations.
The plot takes place against the background of the dot.com crash, and the Twin Towers attack, and a complex financial fraud (the main character Maxine is a fraud investigator, working freelance and on her own time for most of the book), so it's sometimes hard to follow. I suspect I missed some of it, but it doesn't seem to have detracted from my enjoyment. It even made me want to visit New York again, which probably isn't going to happen.