A romcom with degenerative diseases. Jake Gyllenhaal is a smart young man from a good family but he's working in sales because...something about not wanting to give his doctor father the satisfaction he would get from Jake finishing med school. So his start-up millionaire geek brother gets him a job as a medical rep, where he meets early-stage Parkinson's sufferer Anne Hathaway. They engage in the kind of verbal sparring that always means they are about to have sex in this sort of film, and then they have sex. Very energetic, young-people sex. Anne Hathaway's condition is very mild (her hand twitches a bit every so often) but it hangs over them.
He works for Pfizer, so soon he's pushing Viagra rather than Zoloft, and becomes much in demand. Cue some stiffy jokes, and an orgy scene. Then it all gets serious when he realises he really really loves her, and she doesn't want him to take on a future in which she will degenerate...and on to the resolution, which there's no need for me to spoil. Not quite your usual romcom - slightly more gravitas, but still plenty of dick and wanking jokes.